Based on the nickel-base alloy production platform of Fushun Special Steel Co.， LTD.， this paper studies the feasibility of "30 t non-vacuum induction furnace-external furnace refining-electroslag remelting" process instead of the traditional high cost process to smelt nickel-base alloys with high molybdenum content， and analyzes the production efficiency and cost advantages combined with the production practice. The results show that by degassassing smelting process scheme with 30 t non-vacuum induction furnace was used to melt molten steel ， VOD blowing oxygen and decarbonized after vacuum to below 67 Pa， and the smelting of nickel-base alloy N06625 and N10276 products with high molybdenum content was successfully realized.The steel ingot produced after electroslag is 204 mm forging products， the chemical composition and non-metallic inclusions meet the industry standard requirements， and further improve the production guarantee and cost control ability of high molybdenum nickel-base alloy.